corresponding to Mouse Metabotropic Glutamate Receptor 4/MGLUR4
Isotype
IgG
Purity
Affinity purification
Subcellular location
Cell membrane
Uniprot ID
Q68EF4
Applications
Applications
Species
Dilution
Positive Sample
IHC/IF
Mouse, Rat
1: 1000-1: 2000
striatum, brain
Background
L-glutamate
is the major excitatory neurotransmitter in the central nervous system
and activates both ionotropic and metabotropic glutamate receptors.
Glutamatergic neurotransmission is involved in most aspects of normal
brain function and can be perturbed in many neuropathologic conditions.
The metabotropic glutamate receptors are a family of G protein-coupled
receptors, that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and pharmacologic
properties. Group I includes GRM1 and GRM5 and these receptors have been
shown to activate phospholipase C. Group II includes GRM2 and GRM3
while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III
receptors are linked to the inhibition of the cyclic AMP cascade but
differ in their agonist selectivities. Several transcript variants
encoding different isoforms have been found for this gene.
Images
Immunohistochemistry of paraffin embedded mouse striatum using GRM4 (GB113895) at dilution of 1: 2000 (200x lens
Immunohistochemistry of paraffin embedded rat brain using GRM4 (GB113895) at dilution of 1: 1500 (200x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer
PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .