Anti -Perforin Rabbit pAb

價格：在線咨詢

貨號：

636

產品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產品詳情操作說明注意事項

Product Information

Description	Perforin rabbit polyclonal
Protein full name	Perforin-1
Synonyms	P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, FLH2, HPLH2, MGC65093, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, PGFL, PIGF, PIGF-2, PLGF, SHGC-10760
Immunogen	KLH conjugated Synthetic peptide corresponding to Human Perforin
Isotype	IgG
Purity	Affinity purification
Predicted MW.	61 kDa
Observed MW.	70 kDa
Uniprot ID	P14222, P35763

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Rat	1: 500-1: 1000	thymus, spleen, lung

Background

Perforin 1 is one of the major cytolytic proteins of cytolytic granules. It is known to be a crucial effector molecule in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. This protein has structural and functional similarities to complement component C9. Like C9, this protein creates transmembrane tubules and is capable of lysing nonspecifically a variety of target cells. Defects in PRF1 are the cause of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood，which is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. Alternative splicing results in multiple transcript variants encoding the same protein.

Images

Western blot analysis of Perforin (GB11943) at dilution of 1: 800

Lane 1: Jurkat cell lysate

Lane 2: THP-1 cell lysate

Lane 3: SW480 cell lysate

Lane 4: Mouse thymus tissue lysate

Lane 5: Rat spleen tissue lysate

Lane 7: Rat lung tissue lysate

Lane 8: Rat thymus tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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