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Anti -RB-1 Rabbit pAb

價格: 在線咨詢
貨號:
DRF101235
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
M/R,M/R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

RB-1 rabbit polyclonal

Protein full name

Retinoblastoma-associated protein

Synonyms

pRb, Rb, pp105, Rb1

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse RB-1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P13405, P33568




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 700-1: 1400

brain, kidney, lung, skeletal muscle

IF

Mouse, Rat

1: 500-1: 2500

brain, kidney, lung, skeletal muscle




Background


RB1 belongs to the retinoblastoma protein family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1/H2, leading to epigenetic transcriptional repression. RB1 controls histone H4 'Lys-20' trimethylation and inhibits the intrinsic kinase activity of TAF1. It mediates transcriptional repression by Smarxa4/Brg1 by recruiting a histone deacetylase complex to the c-FOS promoter. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.




Images


Immunohistochemistry analysis of paraffin-embedded mouse brain using RB-1 (GB111111) at dilution of 1: 1400

Immunohistochemistry analysis of paraffin-embedded rat brain using RB-1 (GB111111) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat kidney using RB-1 (GB111111) at dilution of 1: 2000

Immunohistochemistry analysis of paraffin-embedded rat lung using RB-1 (GB111111) at dilution of 1: 1400

Immunohistochemistry analysis of paraffin-embedded mouse skeletal muscle using RB-1 (GB111111) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded mouse brain using RB-1 (GB111111) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded rat brain using RB-1 (GB111111) at dilution of 1: 1000

Immunofluorescent analysis of paraffin-embedded rat kidney using RB-1 (GB111111) at dilution of 1: 1000

Immunofluorescent analysis of  paraffin-embedded rat lung using RB-1 (GB111111) at dilution of 1: 1000

Immunofluorescent analysis of  paraffin-embedded mouse skeletal muscle using RB-1 (GB111111) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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